RxCIPIENTS® GL Series
(precipitated silica)

MASS FLOW: EMPIRICAL TEST RESULTS
When tested against colloidal silica, the results were clear: RxCIPIENTS GL100 and GL200provide superior mass flow performance.

Colloidal silica, RxCIPIENTS GL100, and RxCIPIENTS GL200 each were mixed with a 50:50 blend of impalpable lactose and Avicel PH- 101. All powders were screened through a 20-mesh screen and blended in a twin shell blender for 10 minutes. Mass flow was conducted as follows: A 50-gram sample was tested using the FMC Vibratory Feeder and BalanceLink Software from Mettler-Toledo. Dynamic mass flow data was collected every second over a 90 second time period, using the lowest vibration setting that facilitated flow through the 8-mm orifice of the stainless steel funnel. Graphs of mass accumulation versus time were generated and the mass flow rate was calculated. (See figures 1 and 2 for test data.)

FIGURES 1 AND 2: INFLUENCE OF GLIDANTS ON MASS FLOW PR

The results show that blends containing RxCIPIENTS glidants had faster, more uniform flow than those using colloidal silica. RxCIPIENTS GL100 improved the flow of the formulation by 11.3% and 17.0% at 0.2% and 0.5% use levels, respectively, as compared to colloidal silica. RxCIPIENTS GL200 improved the flow of the granulation versus colloidal silica by 13.0% and 17.4%, respectively, at 0.2% and 0.5% use levels.